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no reaction initially, other than the sore arm that showed up the next day and was pretty much gone a few days later

It has been proposed that information from these sensory afferents is sufficient to stimulate the central respiratory control system and alter respiratory pattern independent of acidification of cerebrospinal fluid ( Pathological insults associated with central or obstructive apneas can alter chemoreceptor function, change chemoreflex integration in the central nervous system, and/or alter the properties of the central respiratory network (Levy et al., 2008) and thus may play a role in perpetuating SA via creation of a positive feedback loop

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the second is that the long-term stimuli-increased secretory activity leads to a depletion of the releasable insulin of -cells 31

doi: 10.3389/fphar.2025.1516601 Received 24 October 2024 Accepted 04 February 2025 Published 24 February 2025 Volume 16 - 2025 Edited by Ewa Litwa, Polish Academy of Sciences, Poland Reviewed by Stefano Comai, University of Padua, Italy Archita Venugopal Menon, Beam Therapeutics, United States Updates Copyright 2025 Zhao, Ren, Luo, Li, Cheng, Wen, Wu and Zhou