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Since it can be formed from these three amino acids in the body, it is deemed non-essential, in that it does not have to be obtained from food

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Vitamin B12 (Hydroxocobalamin) is a cobalt-containing essential vitamin central to red blood cell formation, nervous system function and methylation pathway support

The literature search supports the conclusion that metformin is neuroprotective against DM-induced neuronal cell degeneration in both peripheral and central nervous systems, and this effect is likely mediated via modulation of oxidative stress, inflammation, and cell death pathways.
