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This flexibility allows for use in a variety of laboratory tests and studies

doi: 10.3390/ijms17060939 83 IzzoGFrancescoAFerraraDCampitielloMRSerinoIMinucciSet al

For instance, Angiogenesis is promoted by HIF-1 to stimulate the vascular endothelial growth factor (VEGF) pathway in gastric cancer (79)

Transported drugs include numerous anticancer agents (e.g., doxorubicin, vinblastine, and paclitaxel), antiviral compounds (e.g., ritonavir), Ca ++ -channel blockers (e.g., diltiazem), digoxin, antibiotic and antifungal drugs (e.g., erythromycin and ketoconazole), hormones (e.g., testosterone), and immunosuppressants (e.g., cyclosporine)

A key unresolved question is whether compartment-specific GSH pools differentially determine ferroptosis initiation at mitochondrial versus non-mitochondrial membranes