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Repeated freeze-thaw cycles should be avoided when possible, as each cycle can cause incremental loss of activity through partial aggregation

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Additionally, our transmission electron microscopy (TEM) observations align with this model: as lipid-soluble compounds, ARTs (e.g., DHA) can enter lipid droplets within the parasitic digestive vacuolea phenomenon consistent with prior studies [33]and disrupt the regular agregation of heme into hemozoin crystals

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[DOI] [PMC free article] [PubMed] [Google Scholar] 167.Garcia-Rodriguez F.J., Martinez-Fernandez C., Brena D., Kukhtar D., Serrat X., Nadal E., Boxem M., Honnen S., Miranda-Vizuete A., Villanueva A., Ceron J
