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If AngII activation of the AT 1 receptor subtype results in facilitation of the NADPH oxidase complex and formation of free radicals, then blockade of the AT 1 receptor should serve a protective function
Dimitroulas T, Lambe T, Raphael JH, Kitas GD, Duarte RV
Kalivas et al., 2005)
These receptors have a distinct structure with a long extracellular N-terminal and a self-hydrolysis site known as the GPS motif that enables their self-activation without ligand binding
Individual response variation means some users find benefit at lower doses while others require higher amounts
