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At the meantime, a relatively high level of CD38 is expressed on NK cells, inducing antibody-dependent cellular cytotoxicity (ADCC) to kill tumor cells, raising a question of whether the CD38 mAbs have a positive or negative impact on NK cells and what strategy should be used to maximize immune effects against MM cells [9]

S2d) in Ang II Cd38 / mice compared with Ang II WT mice (Supplementary Fig