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At 7 dpf, visually guided OMRs can be reliably recorded 118 and estradiol synthesis and signaling are present 46,47

In mammals, increased consumption of hexose phosphates by phosphofructokinase (PFK) driven by small-molecule PFK agonists can decrease NADPH levels in immune cells, while knockdown of PFK can increase NADPH 40,41

While in vitro vascularization strategies utilizing hydrogel pre-patterning techniques have demonstrated the ability to generate perfusable single vessels [10], they struggle to produce capillary-sized channels due to difficulties in endothelialization, making it challenging to mimic native complex vascular beds [11]

This is where glutathione comes into play as a powerful ally in supporting effective estrogen detoxification

Among various factors, oxidative stress is strongly implicated in AMD [153, 154]