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Figure 2 represents the pathophysiology of an altered IGF-1/GH/insulin axis, and potential beneficial actions of IGF-1 therapy

Documented side effects are usually mild to moderate: Injection-site pain, redness, or bruising Flushing Increased heart rate Nausea or gastrointestinal upset Headache Urinary changes or a fishy body odor at higher choline doses Because these are compounded products, sterile technique, pharmacy sourcing, and formulation verification matter

Combined nicotinamide N-methyltransferase inhibition and lean-diet substitution reduces body weight and liver fat in obese mice

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Histone deacetylase inhibitors: future therapeutics for insulin resistance and type 2 diabetes