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In addition, anaplerotic/cataplerotic pathways in hepatocytes in NAFLD induce mitochondrial O 2 generation and inflammation [9], whereas in NASH, increased NADPH oxidase (NOX)-4 expression may also contribute to hepatic oxidative stress [8]

Dosing adjustments may be needed

Pulmonary hypertension PH is a condition characterized by elevated arterial blood pressure in the pulmonary circulation, placing increased strain on the heart and ultimately leading to heart failure [603]

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