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A strong proof of the crucial role of the transsulfuration pathway in organ and tissue homeostasis was provided by Mota-Martorell and colleagues in 2021, who demonstrated that both the Met cycle and transsulfuration pathway are up-regulated in centenarians

doi: 10.1016/S1074-7613(02)00423-5

In contrast, a small fraction of lymphoma and leukemia cell lines successfully grow in these gels [28, 30], suggesting the presence of TIC or TIC-like cells even in established lymphoma/leukemia cell lines cultured in vitro