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A major constraint is the predominant use of reduced preparations (e.g., in vitro models, acute slices), which fail to capture the integrated milieu of the intact brain
An RCT ( n = 75) using NAC as augmentation strategy was found to be safe and effective for the depressive symptoms in bipolar disorder [136]
Schuler, M., Dierich, A., Chambon, P
Miyazono Y, Gao F, Horie T (2009) Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats
[DOI] [PubMed] [Google Scholar] 268.Nakada T
