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Clinical trials involving approximately 900 participants showed that AOD-9604 had no effect on IGF-1 levels and no negative effects on carbohydrate metabolism

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Therefore, in patients with renal or hepatic insufficiency (or both), arginine is generally avoided or only administered with extreme caution under close monitoring

A 2024 meta-analysis in JCEM, Inositol for Polycystic Ovary Syndrome: Systematic Review and Meta-analysis , found selective metabolic benefits in some contexts, which does not validate MIC injections for universal weight loss

[DOI] [PMC free article] [PubMed] [Google Scholar] 82
