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The connection between collagen and immunity lies in the gut, where approximately 70% of your immune system resides

Pathophysiology Excessive breakdown of heme occurs due to hemolysis, which can be caused by various hereditary and autoimmune diseases that result in deficient red blood cell membranes (such as hereditary spherocytosis), enzyme deficiencies (such asG6PD), and abnormalities in hemoglobin structure

2010, Grande JP, Melder DC, Zinsmeister AR: Modulation of collagen gene expression by cytokines: stimulatory effect of transforming growth factor-beta1, with divergent effects of epidermal growth factor and tumor necrosis factor-alpha on collagen type I and collagen type IV

This makes it a great alternative to synthetic HGH, because it reduces the danger of imbalanced hormone ranges

10.1128/IAI.74.1.504-515.2006 Infect Immun