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Individuals struggling with diabetic nephropathy might experience a more rapid decline in kidney function when they take unusually high doses of vitamin B-12

Injecting into a vein may mean some of the vitamin is wasted, as it can leave the body via the urine

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Vasan RS, Sullivan LM, DAgostino RB et al (2003a) Serum insulin-like growth factor I and risk for heart failure in elderly individuals without a previous myocardial infarction: the Framingham Heart Study
