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Clinical trial data on Tirzepatide, the most structurally similar approved compound, shows that participants maintaining adequate dietary fat had substantially lower gallbladder event rates than those who eliminated fats in an attempt to accelerate weight loss
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Similarly, the upregulation of ZnT5 serves to restore zinc levels in cellular secretory pathways, particularly in the Golgi apparatus, where luminal zinc is loaded onto secreted proteins that require zinc for their catalytic activity (254)
