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We detail research on early infection using evidence from patient samples, organoids and cells, and non-human animal studies

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Altered expression of metabolic proteins also suggest a potential metabolic switch towards pentose phosphate pathway, polyol and hexosamine biosynthesis and purine salvage pathways with less dependency on anabolic gluconeogenesis and fatty acid biosynthesis

In contrast, the HPLC analysis showed treatment with DDTC conferred a significant reduction in intracellular ATP ( 0.6, p 0.007)

Together they create a healing environment that neither achieves alone