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Mori et al., 2014), contributing to more than 85% of NAD + synthesis ( de novo pathway and Preiss Handler pathway synthesize NAD + using nicotinic acid (NA) and tryptophan as substrates, respectively, albeit in smaller quantities

We also see many individuals who follow strict vegetarian or vegan diets, which can increase the risk of B12 deficiency due to limited intake of animal-derived foods
