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Dehydroepiandrosterone is a 1R agonist, which significantly increases the activity of GLT-1 in astrocytes and its transport to the cell surface [202, 203]

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Following the established SUPPA2 pipeline 46 (Methods), we assigned relative abundances of the splicing events or transcript isoforms (referred to as proportion spliced-in (PSI) 47 ) for each transcript across all three timepoints, under four different conditions: T-REX (NCBP1-HNEylation) and three controls (DMSO-alone, light-alone or probe-alone treatment)

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