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Deregulation of their activity may lead to tissue-specific degenerative events that underlie several human pathologies, including cancer, diabetes, and cardiovascular diseases ( via deacetylation of lysine groups of histone and non-histone proteins, including known transcription factors (FOXO, MyoD, p53, PGC-1) ( Chronic inflammation caused by oxidative damage increases the risk of many chronic disorders, including heart, cardiovascular, and neurodegenerative diseases, obesity, insulin resistance, and type 2 diabetes (T2D) ( SIRT1 guards against oxidative stress by activating gene transcription of PGC-1 via deacetylation, and by regulating transcription of factors such as the nuclear receptor peroxisome proliferator-activated receptor (PPAR), nuclear respiratory factor (NRF), and mitochondrial transcription factor A (TFAM), involved in modulation of biogenesis and mitochondrial function ( SIRT1 protects against oxidative stress via regulation of FOXO protein acetylation, which is involved in antioxidant processes, apoptosis, and cell proliferation ( Over the past few years, the ever-growing awareness that good health goes hand in hand with a healthy and balanced diet has encouraged people to eat more fruit and vegetables, and to take supplements to make up for any deficiency ( Most of the evidence supporting the beneficial effects of phytochemical compounds comes from in vitro or animal studies, while human studies evaluating the long-term impact of phytomolecules are particularly few or inconsistent