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Both the thioredoxin (Trx) and GSH-dependent glutaredoxin (Grx) antioxidant systems have been found to reduce methionine sulfoxide reductases in vitro and/or in vivo (see Figure 2 ) (28)
p53 Protein-mediated regulation of phosphoglycerate dehydrogenase (PHGDH) is crucial for the apoptotic response upon serine starvation
Such mutations, if they occur in critical genes like oncogenes or tumor suppressor genes, can drive the transformation of normal cells into malignant ones [98]
JACC Cardiovasc Imaging 17:795810
The six-carbon sugars can be recycled into the pathway in the form of G6P, generating more NADPH
