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Flotillin- 1 ameliorates experimental diabetic retinopathy by inhibiting ferroptosis in blood-retinal barrier

For anatomical imaging, a 3D MP2RAGE 7 was acquired: spatial resolution (1 mm) 3 , flip angle = 4 and 7 deg, echo time TE = 2.27 ms, inversion time TI = 750/2100 ms, T R = 6 ms, volume T R = 5.5 s

Gene 169 281282 10.1016/0378-1119(95)00820-9 [DOI] [PubMed] [Google Scholar] Sachdev D., Chirgwin J

However, a Cochrane systematic review encompassing five randomized controlled trials (415 women) found insufficient very low-quality evidence to support its effectiveness in improving clinical pregnancy rate (RR 1.38, 95% CI 0.91 to 2.10), live birth rate, overall pain, miscarriage rate (Peto OR 1.99, 95% CI 0.20 to 19.37), or endometriosis recurrence (RR 0.84, 95% CI 0.30 to 2.36), highlighting the need for higher-quality trials (65)

The flow cytometry results demonstrated that the RGSH intervention could markedly reduce cell death caused by ferroptosis (Fig