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Many weight-loss interventions cause significant muscle loss alongside fat loss, which can slow metabolism and make weight maintenance difficult

Dan Wool is a naturopathic doctor who specializes in gastroenterology, hormones and men's health in Scottsdale, Arizona

It is a small molecule that works by inhibiting the activity of an enzyme called nicotinamide N-methyltransferase (NNMT)

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doi: 10.1080/00480169.1998.36089
