labial melanotic macule cryotherapy Figure 5 from Cutaneous in maxillofacial surgery What Caused These Multiple Hyperpigmented

By inhibiting autophagy and inducing mitochondrial ROS, TMAO activates NLRP3 inflammasome, leading to the release and pyroptosis of IL-1/IL-18 dependent on caspase-1 in colon epithelium, which is a hallmark of IBD severity

[PubMed] [Google Scholar] Soon SL, Solomon AR Jr, Papadopoulos D, Murray DR, McAlpine B, Washington CV

It also requires suturing and suture removal, and it results in linear scars that may not be as cosmetically pleasing as scars that result from shave excisions

We went through all of them and pulled out the ones that got us really excited

This occurs when melanocytes the pigment-producing cells are mistakenly attacked by the immune system