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These consist of a non-polar core of triglyceride and cholesteryl esters surrounded by a surface layer of phospholipids, cholesterol and proteins known as apolipoproteins (Fig

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Incorporating additional componentssuch as lipoproteins, lipopolysaccharides, PEGylated lipids, or cholesterolcan significantly alter LNP surface properties, modulating the strength and specificity of protein interactions 11,74

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