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Increased serum and brain concentrations of lactate, pyruvate, lactate/pyruvate ratio, alanine, and creatine kinase, at 31%, 14%, 28%, 8%, 47%, 35%, 46%, and 7%, respectively, and low carnitine were described in 90% of children with ASD in the review of Rossignol and Frye [38]

10.1016/S0140-6736(15)60692-4 The Lancet 50 GouldT

Metformin-induced improvement in gut health leads to decreased low-grade inflammation, a very important phenomenon seen in the elderly population that has been named inflammaging [67, 68]

Any performance-related benefits tend to be modest and highly individualised