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The geroscience hypothesis proposes this principle but necessitates experimental testing

Mechanistically, HGF-induced synapse formation is mediated by PI-3K and not MAPK activation, as inhibition of the PI-3K/AKT pathway affects synaptogenesis, while blocking MAPK/ERK does not decrease synapse density and only affects dendritic growth (Peng et al., 2016)

However, there is sufficient evidence that the ventrogluteal IM site is the preferred site whenever possible, and it is an acceptable site for oily and irritating medications

Fibromyalgia and psychiatric comorbidity: their effect on the quality of life patients

If this happens consistently, switch to a 45-degree angle, use a shorter needle, and always pinch the skin when injecting in the thigh