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[DOI] [PMC free article] [PubMed] [Google Scholar] 66.Virmani M.A., Krsmanovic L.Z., Stojilkovic S.S., Catt K.J

Children with CTD should be followed by a metabolic doctor in addition to their primary doctor

Moreover, a percentage of patients ranging between 7 and 25%, depending on different dosage, experience adverse events upon PDE5i treatment [59, 60], sometimes manifesting as of moderate or severe entity, the most frequent of which comprise flushing, headache, dyspepsia, back pain, myalgia, dizziness, and rhinitis [10], although discontinuation rates owing to adverse events of PDE5i is generally relatively low, and comprised between 3 and 5% of patients [61]

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