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A meta-analysis of ten papers that analyzed HCC development in cirrhosis reported a significant reduction in HCC incidence by nucleos(t)ide analog therapy [29]

These are two of the most potent chemotherapeutic drugs, but also two of the most damaging to the kidney owing to the oxidative damage and severe inflammation they produce (Launay-Vacher 2008

Free radicals are highly reactive and can cause oxidative stress, which has been linked to various chronic diseases, such as cardiovascular diseases, certain cancers, and age-related macular degeneration [20]

Notably, the nNOS isoform is also present at the skeletal and cardiac muscle level, namely the nNOS [30,31]

& Tinazzi, M
