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LSECtin on tumor-associated macrophages enhances breast cancer stemness via interaction with its receptor BTN3A3

An imbalance in gut microbiota is thought to drive the chronic inflammation associated with BD that is known to increase risk for both neuroprogression and medical comorbidities (Vaccariello and Nguyen, 2022)

It is structurally similar to transferrin and can chelate two ferric irons (Fe 3+ ), but unlike transferrin, lactoferrin does not release its iron even at low pH

Chemicals such as ATP, TNF- , prostaglandin E2, NGF, bradykinin, serotonin and protons are released by mast cells, macrophages, and epithelial cells to induce peripheral sensitization, which serves to increase pain awareness to limit further damage, fight infection and initiate injury repair

This contributes to maintaining intracellular homeostasis, mitigating the effects of aging, and providing protection against diseases associated with oxidative stress