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There are, however, a few general strategies that can be useful for both conditions: Hives: Antihistamines : These medications can help block the effects of histamine, a chemical released during an allergic reaction that causes hives

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Expect mild nausea in the first 12 weeks

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(So it might be a good idea to combine arbutin with some direct tyrosinase inhibitors for more skin lightening effect.) All in all, arbutin is one of the better-known skin brightening agents, that's probably worth a try if pigmentation is an issue for you