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However, due to the complexity and ethical constraints of clinical trials, it is difficult for the latter to conduct large-scale and long-term follow-up, and in contrast, most clinical RCTs aim at the validation of symptomatic drugs such as calcium, vitamin D, and BPs, while the microecological modifiers that target the gutbone axis are seldom screened

Currently, more recent studies have suggested that reperfusion-induced lipid peroxidation depends on the critical events occurring ischemic stage [250, 251]

6 Gut microbiota dysbiosis and cytokine abnormalities 6.1 Evidence for the association between cytokines and schizophrenia Given the dysfunction of the BBB in patients with schizophrenia, changes in cytokine levels in the periphery (peripheral blood) and the center (cerebrospinal fluid, CSF) are valuable for assessing the CNS inflammatory state

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