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developed mitochondrial-targeting paclitaxel liposomes that selectively accumulate in mitochondria, overcoming resistance in cisplatin-resistant A549 cells by promoting Bax activation and suppressing Bcl- 2 (Zhou et al

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Secondary mitochondrial dysfunction Acquired dysfunction may develop from oxidative stress, inflammation, nutrient deficiency, medication toxicity, toxic exposure, aging, metabolic disease, infection, poor sleep, inactivity or chronic illness