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Iron is essential for the de novo production of DNA as a co-factor of ribonucleotide reductase [496]

BSO treatment was performed similarly as for ITCs by adding it (100 mM stock solution prepared in water) to the medium (either on its own or in combination with ITC) to obtain BSO concentrations ranging from 50 M to 700 M

In recent years, intranasal (IN) drug delivery has emerged as a promising strategy to bypass the BBB, providing a direct nose-to-brain delivery route via olfactory and trigeminal pathways while minimizing systemic exposure

Mishra B, Reiling S, Zarena D, Wang G (2017) Host defense antimicrobial peptides as antibiotics: design and application strategies

For example, the TM6SF2 E167K genotype associates with steatosis but not fibrosis, whereas MBOAT7 rs641738 is solely associated with increased fibrosis