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One theory that attempts to integrate these diverse observations focuses on the lysosomal accumulation of aminoglycosides, with induction of a lysosomal phospholipidosis as the critical first step (Tulkens, 1989)
10.1016/j.tins.2014.07.010 Trends Neurosci
The following variates have to be considered for the estimation of the risk of developing an adjacent segment fracture: including age, gender, bone mineral density (BMD), local kyphotic angle and number of pre-existing fractures before specific therapy
Wound Repair and Regeneration 10(6):369-374
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