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USP2 is lactylated at K447 under TGF1 stimulation and which is required for the activation of USP2-mediated TGF1 We found that the interaction between SIRT2 and USP2, as determined by both endogenous and exogenous co-immunoprecipitation (Co-IP), was present under TGF1 stimulation (Fig

J Asian Nat Prod Res (2009) 11:448

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The ability of NAC to modulate the upregulation of IL-8 has been described in other studies as well: the increased IL-8 gene [56] and protein [57, 58] expression of PQ-challenged peripheral blood mononuclear cells was blocked by NAC [57], and NAC administration was found to inhibit the release of chemotactic factors for neutrophils and consequently reduce their infiltration into the lungs of PQ-challenged rats [9]