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Multi-Pathway Brightening: It addresses skin tone by inhibiting tyrosinase activity and shifting melanin production from dark eumelanin to lighter pheomelanin
INS1 -cell mitochondrial matrix Ca 2+ increases from 100 to 200 nM to 600800 nM, which is slightly higher compared to the increase in cytosolic Ca 2+ , and gradually increases without the oscillatory nature (Wiederkehr et al., 2011)
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In addition, cytokines, microRNAs, and certain interleukins have been evaluated in clinical trials, although their use is not yet widespread in routine clinical practice [36]
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