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[DOI] [PMC free article] [PubMed] [Google Scholar] Gutkind JS, Kostenis E

L., Angelucci, F., Lucia, A., Pareja-Galeano, H., Leyhe, T., Turana, Y., Lee, I

The foremost limitation is the absence of large-scale, randomized, and well-controlled clinical trials capable of establishing definitive evidence of safety and efficacy in human populations

After 48 h of growth in NGF or BDNF, cultures were either maintained with trophic support or deprived of it, in the absence or presence of each specific compound for the entire deprivation period

On the whole, animal studies have found BPC-157 to have a favorable safety profile at research amounts, with no significant toxic effects reported in short- to medium-term rodent studies