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Immunopharmacological implications Physiological levels of ROS, which are present in all living organisms, can activate both signaling pathways such as MAPK and ERK and transcription factors such as NF-B (Sies and Jones, 2020

NNMT and NAD Metabolism By methylating nicotinamide, NNMT consumes NAM that would otherwise feed into the salvage pathways for NAD synthesis , thereby reducing intracellular NAD levels

EMT serves as a critical determinant in the dissemination of CRC cells during tumor migration and invasion

Glutathione peroxidases Five selenium-containing glutathione peroxidases (GPx1-4 and GPx6) have been identified: GPx1 (cytosolic GPx), GPx2 (epithelial cell-specific GPx first identified in intestinal lining and lungs), GPx3 (highly expressed in thyroid gland and kidneys), GPx4 (phospholipid-hydroperoxide GPx

We selected alkaline phosphatase (AP) as a model protein to quantify the oxidation rate