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[DOI] [PubMed] [Google Scholar] 26.Ferrini MG, Kovanecz I, Sanchez S, et al

IMC also prevented diet-driven hepatic cholesterol accumulation and caused both upregulation of the host hepatic bile acid synthetic enzyme CYP7A1 and altered the expression of hepatic genes critical for bile acid feedback regulation

Furthermore, TMAO enhances CaOx crystal deposition via oxidative stress and autophagy-related cell death, impairs renal function, and promotes kidney stones (Kapetanaki et al., 2021) (Figure 9A)

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