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Equol is acknowledged as a byproduct of the isoflavones daidzein or genistein, which are synthesized by the microorganisms present in the gastrointestinal tract [122,123]

Through this intracellular coupling, astrocytes supply neurons with cysteine or cysteinyl-glycine derived from exported GSH, thereby supporting neuronal GSH synthesis and resistance to damaging, redox-driven processes (Kwon et al., 2019)

Science 1956

In these patients, administration of an NSAID may cause a dose-dependant reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal failure
doi: 10.1016/j.kint.2023.01.021