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Xenobiotica 42:872879 Bueno Prez L, Pan L, Sass E, Gupta SV, Lehman A, Kinghorn ADLucas DM (2012) Potentiating effect of the flavonolignan ()-hydnocarpin in combination with vincristine in a sensitive and P-gp-expressing acute lymphoblastic leukemia cell line

ROS play important roles at the ER, where their production activates the unfolded protein response (UPR), accompanied by the inactivating sulfhydration of protein tyrosine phosphatase 1B (PTP1B) that results in the increased phosphorylation and, hence, activation of PERK 91

RNAseq data can be accessed in the Gene Expression Omnibus under accession number GSE217834

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