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Its synthesis also requires several cofactors: vitamin C , vitamin B6 , niacin (B3) and iron

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Treatment consists of pharmacological doses of L-carnitine that are meant to maintain a normal blood carnitine concentration, thereby preventing the risk of hypoglycemia and correcting metabolic and myopathic manifestations (34)

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High plasma TMAO concentrations were associated with increased incidence of all-cause mortality (14 studies for 16 cohorts enrolling 15,662 subjects, hazard ratio: 1.91

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