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A controlled trial that included 30 healthy volunteers with normal hearing found 600 mg lipoic acid daily for 10 days prior to experimental noise exposure reduced temporary noise-induced hearing loss better than a single 600 mg dose of lipoic acid one hour before noise exposure or no lipoic acid

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It is not clear if these devices actually work or are safe to use, and the NHS does not recommend starting this type of treatment without first discussing it with a doctor

50 These studies yielded mixed results with the RCT amongst breast cancer patients demonstrating harm from ALC administration, 48 the RCT of ovarian and prostate cancer patients demonstrating benefit, 49 and the RCT amongst multiple myeloma patients demonstrating no significant difference between ALC and placebo