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As an E3 ubiquitin ligase, FBXO22 mediates the proteasomal degradation of multiple substrates

elevated triglycerides (defined as 150 mg/dL), decreased High Density Lipoprotein (HDL) (ranges below 40 mg/dL in men and 50 mg/dL in women), elevated blood pressure (defined as systolic blood pressure above 130 mmHg or diastolic blood pressure above 85 mmHg) and elevated fasting glucose (defined as blood glucose above 100 mg/dL)

In line with this, emergency use authorizations were granted to support the implementation and roll-out of Pfizer/BioNTechs and Modernas mRNA-based COVID-19 vaccines because of the public health crisis imposed by the COVID-19 pandemic, however, full approvals were subsequently granted

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These figures come from veterinary-derived and clinic sources, not human trials