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rather, some of these enzymes are functionally identified as thioredoxin-dependent peroxidases containing a redox-active Cys in place of the Sec
The researchers found that cisplatin-resistant ovarian cancer cells pretreated with erastin (a ferroptosis inducer) showed increased sensitivity to cisplatin, demonstrating the good synergistic effect of the two drugs (Sato et al., 2018)
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doi: 10.1016/0092-8674(86)90595-7
Active targeting schemes for nanoparticle systems in cancer therapeutics
