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Future research on creatine supplementation and kidney function would greatly benefit from standardized reporting of assay type and calibration method, which would enable more precise synthesis of evidence

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Consequently, these limitations have catalyzed increasing interest in natural metabolites with multi-target pharmacological properties and favorable safety profiles

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This review has mapped their pleiotropic actionsranging from redox buffering and immune modulation to epigenetic reprogrammingand highlighted encouraging preclinical synergy with radiotherapy, chemotherapy, and immunotherapy