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From a medical point of view, it is crucial, as these metabolites are toxic in excess
Wang et al., 2000
Studies involving T cells function during IFN-based therapy for chronic HCV infection indicate a decrease in the quantity and compromised functional capacity of antiviral T cells compared [117, 118] to acute HCV infection, where highly functional T cell responses are observed [118, 119]
R.WilsonK
Similar to thermotaxis, previous thermal experience can modify noxious heat avoidance through a mechanism of phosphorylation and nuclear translocation of CMK-1, in FLP neurons [40]
