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The up-regulation of MOG was associated with an increased production of autoantibodies against MOG protein in AD, indicating early demyelination of the hippocampal region (Papu et al., 2015)

An in vitro study using AD fibroblasts revealed a reduction of oxoglutarate dehydrogenase activity and it was further supported by an in vivo study with AD patients whereby the activity of oxoglutarate dehydrogenase complex was markedly reduced by 46 to 68% [201, 202]

10.1016/j.lfs.2019.116836 34 RazaH.JohnA.HowarthF

This mechanism of Zots action on actin was discovered through exposing rabbit ileal tissue and a rat small intestinal cell line, IEC-6 cells, to Zot and observing subsequent changes to the F-actin cytoskeleton