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This loop is the storage mechanism for B12 in normal mammals as the intrinsic factor from the stomach holds onto the B12 and saves it for the ilium to recover and send to the liver

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Have gastrointestinal conditions that impair nutrient absorption (e.g., IBS, celiac disease, or Crohns)

For those who prioritize convenience and want to avoid any reconstitution errors, pre-mixed is the simpler option

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