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For instance, anthocyanin-derived metabolites such as protocatechuic acid (100 mg/kg after onset until death, 1 time/day, 5 times/week) (67) and anthocyanin-enriched strawberry extract (2 mg/kg/day after 60 days of age until death) (68), were shown to attenuate spinal cord astrogliosis, inhibit motor neuron apoptosis, and preserve neuromuscular junction integrity in SOD1 mutant micea widely used ALS model

The poorly characterised DENND11 also possessed a PL motif but did not display a sufficient confidence binding score with Retromer subunits, and expressed GFP-DENND11 showed weak association with Retromer when immuno-isolated from HEK cells, independently of the PL motif (Supplementary Fig

Control HT-1080 N : DMSO, 0.3 10 5 , gemcitabine, 1.52 10 5

Tang G, Gudsnuk K, Kuo S-H, Cotrina ML, Rosoklija G, Sosunov A, et al